I am a researcher developing Brain-on-Chip model to better understand the mechanisms of depression and the effects of antidepressants. Globally, an estimated 5.7% of adults suffer from depression (WHO, 2025), yet many aspects of its biology and treatment response remain poorly understood.
In my research, I develop neurovascular unit (NVU) models by integrating the blood–brain barrier (BBB) with glial cells and neurons, enabling the study of neurovascular interactions and the effects of antidepressants. The BBB is recreated using an innovative Double Viscous Finger Patterning approach to form physiologically relevant 3D microvascular structures, while chronic stress-induced inflammation is modeled through hormone-based stimulation to investigate its impact on barrier integrity, permeability, and signaling. To further enhance physiological relevance, the platform is integrated with a liver-on-chip module, allowing assessment of drug metabolism and its influence on antidepressant treatment response.
Behind the scenes, I learn French, work with clay, dance, and handle promotion and social media for MicroOrganChip.